The small interfering RNA pathway is not essential for Wolbachia-mediated antiviral protection in Drosophila melanogaster.

نویسندگان

  • Lauren M Hedges
  • Ryuichi Yamada
  • Scott L O'Neill
  • Karyn N Johnson
چکیده

Wolbachia pipientis delays RNA virus-induced mortality in Drosophila spp. We investigated whether Wolbachia-mediated protection was dependent on the small interfering RNA (siRNA) pathway, a key antiviral defense. Compared to Wolbachia-free flies, virus-induced mortality was delayed in Wolbachia-infected flies with loss-of-function of siRNA pathway components, indicating that Wolbachia-mediated protection functions in the absence of the canonical siRNA pathway.

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عنوان ژورنال:
  • Applied and environmental microbiology

دوره 78 18  شماره 

صفحات  -

تاریخ انتشار 2012